구강조직유래 유도만능줄기세포- 생체재료 복합체의 재생의료 동향
Regenerative medicine using dental tissue derived induced pluripotent stem cellbiomaterials complex
전수경, 이해형, 김해원, 이정환,
소속 상세정보
전수경 ( Jun Soo-Kyung ) - 단국대학교 치과대학 생체재료학교실
이해형 ( Lee Hae-Hyoung ) - 단국대학교 치과대학 생체재료학교실
김해원 ( Kim Hae-Won ) - 단국대학교 치과대학 생체재료학교실
이정환 ( Lee Jung-Hwan ) - 단국대학교 치과대학 생체재료학교실
KMID : 0362720170550120828
Abstract
In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (ectomesenchymal) origin, which easily differentiate them to various cell types for nerve, vessel, and other dental tissue regeneration. In other part, utilizing biomaterials for regenerative medicine using cell is recently highlighted because they can modulate cell adhesion, proliferation and (de)differentiation. Therefore, this paper will convey the overview of advantages and drawbacks of dental tissue-derived iPSCs and their future application with biomaterials.
키워드
Regenerative medicine; dental tissue derived; induced pluripotent stem cell; biomaterials
원문 및 링크아웃 정보
등재저널 정보